COMPOUND WHICH IS PRO-DRUG OF LANOSTEROL, AS WELL AS METHOD FOR PRODUCTION THEREOF AND USE THEREOF Russian patent published in 2020 - IPC C07J9/00 A61K9/08 A61K31/575 A61P27/12 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to compounds of formula (I), (II) or (III), a pharmaceutically acceptable salt or stereoisomer thereof,

where m equals 0 or 1, wherein if m equals 0, fragment is absent; n equals 0; R₁ denotes C₁ alkyl-O-C(=O)-C₂ alkyl-NH-; R₂ denotes phenyl-O-; R₃ is selected from a group consisting of 6-member aryl and 5–10-member heteroaryl, each of which is optionally substituted with 1 or 2 R, but R₃ is not phenyl and ; wherein in R₃, when R is NO₂, 6-member aryl or 5–10-member heteroaryl is optionally substituted with 1 R; R₅ is H; R₆ is H; R₇ denotes H or phenyl; R₈ is H; R₉ is H; each of R independently represents F, NO₂, OH, CN, CH₃, CF₃ or CH₃C(=O)-O-; Hetero in 5–10-member heteroaryl is independently selected from a group consisting of N and -O-; wherein in any of the above cases, the number of heteroatoms or heteroatom-containing groups independently represents 1, 2 or 3. Compounds presented by a group of specific compounds, a pharmaceutical composition and use are also disclosed.

EFFECT: technical result is obtaining novel organic compounds which are characterized by higher penetrating power than lanosterol, and which are used in preparing a drug preparation for treating cataract.

9 cl, 6 dwg, 9 tbl