FIELD: biotechnology; medicine.
SUBSTANCE: invention refers to biotechnology and veterinary medicine. Disclosed is a method of producing an inactivated vaccine against pulmonary diseases of young animals of productive animals. Method includes Streptococcus pneumonia cultivation in nutrient medium at initial concentrations of microorganisms 4–7 billion m.t./cm3, at pH 6.8–7.24, limiting growth of streptococci glucose; oxidation-reduction potential of culture liquid −200 ÷ −150 mV and pO2 – 5–25 % of saturation with air oxygen. Streptococcus pneumonia culture is inactivated by formaldehyde with final concentration of 0.03–0.07 % at 41–45 °C for 3–5 days, then an adjuvant - aluminium hydroxide is added.
EFFECT: invention provides higher quality of vaccine for protection of young stock of productive animals against pulmonary diseases.
1 cl, 1 tbl, 6 ex
Title | Year | Author | Number |
---|---|---|---|
POLY-STRAIN FORMOLATED VACCINE AGAINST CALVES PNEUMONIA STREPTOCOCCAL ETIOLOGY | 2018 |
|
RU2687488C1 |
METHOD FOR PREPARING VACCINE WITH ALUMINIUM HYDROXIDE AGAINST MASTITIS OF COWS STREPTOCOCCAL AETIOLOGY | 2019 |
|
RU2723711C1 |
METHOD OF MANUFACTURE OF FORMOLVACCINE OF HYDROOXYALUMINUM POLYSTAMMAL AGAINST STREPTOCOCCAL DISEASES OF LARGE CATTLE | 2016 |
|
RU2649754C2 |
ASSOCIATED ALUMINIUM HYDROXIDE VACCINE AGAINST INFECTIOUS PNEUMONIA OF BACTERIAL ETIOLOGY IN PIGS AND METHOD FOR ITS MANUFACTURING | 2000 |
|
RU2191598C2 |
POLYVALENT INACTIVATED VACCINE AGAINST SWINE STREPTOCOCCOSIS, METHOD FOR ITS PRODUCTION AND USE | 2021 |
|
RU2761379C1 |
METHOD OF OBTAINING VACCINE ASSOCIATED WITH COLIBACILLOSIS, STREPTOCOCCOSIS AND ENTEROCOCCAL INFECTION OF CALVES AND PIGLETS | 2017 |
|
RU2650628C1 |
METHOD OF PRODUCING ASSOCIATED VACCINE AGAINST STREPTOCOCCOSIS AND STAPHYLOCOCCOSIS OF CATTLE | 2009 |
|
RU2406532C1 |
MIXED INACTIVATED ALUMINUM HYDROXIDE-CONTAINING VACCINE AGAINST INFECTIOUS PNEUMONIA AND SALMONELLOSIS IN PIGS AND METHOD FOR IT PREPARING | 2003 |
|
RU2246316C1 |
STRAIN OF BACTERIUM STREPTOCOCCUS AGALACTIAE 71 FOR PREPARING VACCINE AGAINST STREPTOCOCCOSIS IN FUR ANIMAL | 2004 |
|
RU2261109C1 |
POLYVALENT VACCINE AGAINST SALMONELLOSIS OF PRODUCTIVE ANIMALS | 2021 |
|
RU2764118C1 |
Authors
Dates
2020-06-02—Published
2019-06-20—Filed