FIELD: biotechnology.
SUBSTANCE: inventions group relates to the field of biotechnology. The proposed vaccine against swine streptococcosis, polyvalent inactivated, contains the following components per one immunizing dose of the drug (2 cm3): formalin-inactivated protective antigens of Streptococcus suis strains No. UR-4-VBH - 3.5 billion mcr. cl.; Streptococcus porcinus UR-3-VBH - 3.5 billion mcr. cl.; Streptococcus pyogenes OB-4-VBH - 3.5 billion mcr. cl.; Streptococcus dysgalactiae UR-16-VBKh - 3.5 billion mcr. cl., as well as pharmaceutically acceptable target additives. The method for obtaining a vaccine includes the cultivation of industrial strains; inactivation of the culture fluid; concentration of antigens; determination of the completeness of antigen inactivation; preparation of a vaccine batch; control of the sterility of the vaccine and the safety of the vaccine; determination of the immunogenic and antigenic activity of the vaccine. The vaccine is used as a prophylactic agent when administered to pregnant sows intramuscularly in the upper third of the neck (behind the ear) in a dose of 2 ml twice: the first time - 50-55 days before farrowing, the second time - 25-30 days before farrowing. Subsequently, the vaccine is administered 25-30 days before each subsequent farrowing once in the same dose. It is not allowed to vaccinate sows later than 25-30 days before farrowing, as well as lactating animals. Piglets are vaccinated starting at 14 days of age. The vaccine is injected intramuscularly into the femoral muscle group twice with an interval of 21-24 days at a dose of 2 ml, additional revaccination is carried out at the age of 4 months. once.
EFFECT: vaccine has enhanced immunogenic and antigenic activity, induces intense and long-term immunity in pigs against streptococcosis caused by S. suis, S. dysgalactiae, S. porcinus and S. pyogenes species, which significantly distinguishes it from the existing vaccines of this direction.
8 cl, 5 tbl, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| VACCINE AGAINST INFECTIOUS ATROPHIC RHINITIS AND PASTERELLOSIS IN PIGS INACTIVATED, METHOD FOR ITS PREPARATION | 2021 |
|
RU2763991C1 |
| STRAIN OF BACTERIA STREPTOCOCCUS DYSGALACTIAE FOR MAKING BIOPREPARATIONS FOR SPECIFIC PREVENTION OF MASTITIS IN COWS | 2023 |
|
RU2818361C1 |
| METHOD OF MANUFACTURING ASSOCIATED VACCINE AGAINST COLIBACTERIOSIS, STREPTOCOCCOSIS AND ENTEROCOCCAL INFECTION OF CALVES AND PIGLETS | 2010 |
|
RU2429012C1 |
| METHOD OF PRODUCING INACTIVATED VACCINE AGAINST PULMONARY DISEASES OF YOUNG ANIMALS OF PRODUCTIVE ANIMALS | 2019 |
|
RU2722668C1 |
| POLY-STRAIN FORMOLATED VACCINE AGAINST CALVES PNEUMONIA STREPTOCOCCAL ETIOLOGY | 2018 |
|
RU2687488C1 |
| SA-21 STRAIN OF BACTERIA OF STREPTOCOCCUS GENUS OF STREPTOCOCCUS AGALACTIAE SPECIES FOR THE MANUFACTURE OF BIOLOGICAL PRODUCTS FOR THE SPECIFIC PREVENTION OF MASTITIS IN COWS | 2022 |
|
RU2799603C1 |
| METHOD OF OBTAINING VACCINE ASSOCIATED WITH COLIBACILLOSIS, STREPTOCOCCOSIS AND ENTEROCOCCAL INFECTION OF CALVES AND PIGLETS | 2017 |
|
RU2650628C1 |
| METHOD FOR MANUFACTURING ASSOCIATED VACCIONE AGAINST COLIBACTERIOSIS, SALMONELLOSIS, STREPTOCOCCOSIS AND ENTEROCOCCAL INFECTION IN NUTRIAS | 2006 |
|
RU2316345C1 |
| STRAIN OF BACTERIUM STREPTOCOCCUS PYOGENES 289 USED FOR PREPARING VACCINE AGAINST STREPTOCOCCOSIS IN FUR ANIMAL | 2004 |
|
RU2263143C2 |
| MIXED INACTIVATED ALUMINUM HYDROXIDE-CONTAINING VACCINE AGAINST INFECTIOUS PNEUMONIA AND SALMONELLOSIS IN PIGS AND METHOD FOR IT PREPARING | 2003 |
|
RU2246316C1 |
