SUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR PREVENTING AND TREATING DIABETES Russian patent published in 2020 - IPC A61K31/192 A61P3/06 A61P3/08 A61P3/10 A61P5/50 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to use of a compound represented by formula I or a pharmaceutically acceptable salt thereof for preparing a medicament for preventing and/or treating type I diabetes, type II diabetes, type III diabetes (Alzheimer's disease) or gestational diabetes. Said medicinal agent is intended for administering a compound represented by formula I or a pharmaceutically acceptable salt thereof in dose of 0.1 to 5 mg/kg a day. Formula I is

Formula I,

wherein A is C₅ alkyl, C₆ alkyl, C₅ alkenyl or C₆ alkenyl; R₁ denotes H, F or OH; R₂ is C₅ alkyl, C₆ alkyl, C₅ alkenyl or C₆ alkenyl; R₃ is H, F, OH or CH₂Ph; R₄ represents H, F or OH; Q represents (CH₂)_mC(O)OH, wherein m represents 1 or 2, CH (CH₃)C(O)OH or C(CH₃)₂C(O)OH. Also disclosed are use of a compound of formula I for preparing a medicament for modulating glucose, insulin and/or triglyceride levels, use of compound with formula I for preparing a drug for increasing insulin secretion, and/or increasing insulin sensitivity, and/or reducing insulin resistance, using the compound of formula I to reduce blood triglycerides.

EFFECT: disclosed are substituted aromatic compounds and pharmaceutical compositions for preventing and treating diabetes.

31 cl, 9 dwg, 3 tbl, 4 ex