METHOD FOR DETERMINING AGGRESSIVENESS OF LUNG CANCER Russian patent published in 2020 - IPC A61B5/00 A61B6/00 G01N33/48 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to oncology, and can be used for determination of aggressiveness degree of lung cancer. Factors influencing the lung cancer prognosis are determined: sex, age, height, weight, body mass index, constitution, type of nervous system, blood group, Rhesus factor, burdened history, environmental factors, nature of work, occupational hazards, smoking, smoking duration, number of X-ray examinations, air travel, sleep, number of meals, amount of liquid consumed, amount of alcohol taken per month, previous diseases of trachea, bronchi, lung, haemostasis disorders, tumour markers, tumour histology, degree of differentiation, tumour growth pattern, size of tumour node, number of foci, presence of metastases, sensitivity to radiation and drug therapy. Degree of influence of each factor is assessed in terms of points, namely: gender: man - 2 points, woman - 1 point; age: younger than 49 years old - 1 point, 50–59 years old - 2 points, 60 years old and older - 3 points; growth: up to 160 cm - 2 points, 160–169 cm - 1 point, 170 cm and higher - 2 points; weight: up to 60 kg - 3 points, 60–89 kg - 2 points, 90 kg and more - 1 point; body weight index: BMI less than normal - 3 points, BWI (norm - 18.5–24.5) - 2 points, BWI more than norm - 1 point; constitution: ectomorph - 2 points, normosthenic - 1 point, hypersthenic - 2 points; type of nervous system: phlegmatic - 2 points, sanguine person, melancholic - 1 point, choleric - 2 points; blood group: 1–2 points, III and IV - 1 point, II - 2 points; Rhesus factor: Rh + - 1 point, Rh- - 2 points; burdened history: no - 2 points, one - 1 point, two or more - 2 points; environmental factors - contamination, passive smoking: no - 1 point, is - 2 points; nature of work: mental - 2 points, mixed - 1 point, physical - 2 points; occupational hazards: there is - 2 points, not - 1 point; smoking - number of cigarettes a day: no - 1 point, up to 20 - 2 points, more than 20 - 3 points; smoking duration: up to 10 years - 1 point, 10–20 years - 2 points, more than 20 years - 3 points; number of X-ray examinations: no - 1 point, to 60 - 2 points, 60 and more - 3 points; air travels: up to 160 hours - 1 point, more than 160 hours - 2 points; sleep duration: up to 7 hours - 2 points, 7–8 hours - 1 point, more than 8 hours - 2 points; number of meals: 1–2–3 points, 3–2 points, 4 and more - 1 point; amount of liquid drunk: up to 1 l - 2 points, 1–2 l - 1 point, more than 2 l - 2 points; amount of alcohol taken per month (40°): no - 1 point, to 1 l - 1 point, 1–2 l - 2 points, 2 l and more - 3 points; previous diseases of trachea, bronchi, lung: no - 1 point, yes - 2 points; disturbed homeostasis: no - 1 point, is - 2 points; tumour markers: no - 1 point, is - 2 points; histology of tumour: squamous cell - 1 point, adenocarcinoma - 2 points, small-cell - 3 points, others - 3 points; degree of differentiation: high - 1 point, moderate - 2 points, low - 3 points; tumour growth pattern - nodal growth - 1 point, mixed growth - 2 points, infiltrative value - 3 points; tumour node size: up to 3 cm - 1 point, 3–5 cm - 2 points, more than 5 cm - 3 points; number of foci: one - 1 point, two - 2 points, three points - 3 points; presence of metastases: no - 1 point, l/nodes - 2 points, in other organs - 3 points, multiple in other organs - 4 points; sensitivity to radiation and drug therapy: there is - 1 point, no - 2 points. Then degree of aggressiveness of lung cancer is calculated by formula

,

where S - level of aggressiveness, in units; P - factor affecting prognosis, points; n is number of factors. If S is equal to 1.5 units I degree of aggressiveness is determined, from 1.5 to 2 units - II degree of aggressiveness, more than 2 units - III degree of aggression.

EFFECT: method provides accurate determination of a degree of aggressiveness of the clinical course by enlarging the list of factors influencing the lung cancer prognosis by taking into account the factors characterizing the tumour body (patient) itself, external factors influencing protective-adaptive reactions of an organism and tumour reaction on conducted conservative treatment (radial, medicinal).

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