METHOD FOR CORRECTION OF BACTERIAL PURULENT MENINGITIS WITH BIS (2-ETHYL-6-METHYL-3-HYDROXYPYRIDINIUM)2,6-DICHLOROPHENYL (AMINO)PHENYLETHANOATE UNDER EXPERIMENTAL CONDITIONS Russian patent published in 2021 - IPC A61K31/4425 A61K31/545 A61P31/04 

FIELD: medicine, experimental pharmacology in particular.

SUBSTANCE: invention relates to medicine, in particular to experimental pharmacology, neurology and infectious diseases, and can be used for the treatment of bacterial purulent meningitis. The method for correcting bacterial purulent meningitis in the experiment consists in simulating bacterial purulent meningitis in rats by injecting 10 µl of a suspension containing Streptococcus pneumoniae at a concentration of 5*10⁹ CFU/ml into the subarachnoid space. Subsequent correction is performed by bis (2-ethyl-6-methyl-3-hydroxypyridinium)2,6-dichlorophenyl (amino)phenylethanoate at a dosage of 25 mg/kg, which is administered 7 hours after the induction of meningitis intramuscularly once, and followed by correction with ceftriaxone, initiated 18 hours after the induction of meningitis, at a dosage of 100 mg/kg/day intramuscularly once a day for 7 days.

EFFECT: invention provides a pronounced correction of bacterial purulent meningitis, which is confirmed by high recovery rates of neurological and cognitive functions, as well as rapid recovery of behavioral activity and low mortality.

1 cl, 5 tbl, 1 ex