METHOD OF SYNTHESIS OF NOVEL COMPOUNDS OBTAINED FROM 3-HYDROXYCYCLOPENTYLACETIC ACID Russian patent published in 2020 - IPC C07C45/69 C07C47/222 C07C51/00 C07C59/11 C07C59/54 C07C59/56 C07C59/64 

Abstract RU 2726412 C2

FIELD: chemical or physical processes; cosmetic industry.

SUBSTANCE: present invention relates to a method of producing a compound of formula (I), where R1 denotes a hydrogen atom, R2 denotes a radical, selected from: a linear or branched saturated hydrocarbon radical containing 1–12 carbon atoms; -Ar-R22 radical, where Ar is an aromatic nucleus selected from a phenyl group, and R22 is a substitute selected from hydrogen, -OR' and -CF3, where R' denotes a hydrogen atom or a linear or branched saturated hydrocarbon radical containing 1–6 carbon atoms; radical -R23-Ph, where R23 is a linear or branched saturated hydrocarbon divalent radical containing 1–6 carbon atoms, optionally substituted with 1–3 groups -OH; and also optical isomers thereof, diastereoisomers and/or corresponding salts; where the method includes the following steps: a) 1,4-bonding to acrolein an alkyne of formula R2C≡CH, where R2 is as defined in formula (I); b) product cyclisation, obtained at the end of step a), by intramolecular hydroacylation; c) 1,4-bonding to cyclopentenone obtained from step b), malonate derivative CH2(CO2CH2Ph)(CO2R0), where -R0 is -CH2Ph; d) reduction and decarboxylation of the product obtained at step c). Invention also relates to a cosmetic composition.

EFFECT: disclosed is a method of synthesis of novel compounds obtained from 3-hydroxycyclopentylacetic acid.

8 cl, 2 tbl, 7 ex

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RU 2 726 412 C2

Authors

Dalko Mariya

Marat Ksave

Its Zhyulen

Li Chao-Tszyun

Dates

2020-07-14Published

2016-03-14Filed