FIELD: medicine; pharmaceuticals.
SUBSTANCE: group of inventions relates to the field and specifically to use of a compound of formula I: I, where E1 is H, OH or NH2; E2 is H, OH or NH2; E3 is H, OH or NH2; E4 is H, OH or NH2; A is H or NH2; D is
; or A and D form 6-member ring of formula:
; G is N; L1 is OH; for treating a fibrotic disease. Group of inventions also relates to a method of treating a fibrosing disease by administering said compounds; pharmaceutical composition containing said compounds, and commercial package containing said compositions.
EFFECT: group of inventions provides new agents and methods of treating fibrosis.
35 cl, 13 ex, 19 dwg
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Authors
Dates
2020-07-14—Published
2014-06-04—Filed