METHOD FOR PREDICTION OF THE EFFECTIVENESS OF GASTROENTEROLOGICAL DISORDERS CORRECTION IN CHILDREN WITH AUTISM SPECTRUM DISORDERS Russian patent published in 2020 - IPC G01N33/50 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to pediatrics, and can be used as an auxiliary method when designing a treatment plan for patients with autism spectrum disorders. Proposed method comprises collecting anamnesis data, determining parameters of nutritional status, serological and genetic markers of gluten intolerance in children with autism spectrum disorders. Obtained data are used to construct a regression equation: K_pr(gastro)=-0.544663+0.00573263*P01+0.302147*P02+0.0152668*P03-0.0156986*P04+0.0524337*P05-0.0901907*P06+0.0245465*P07+1.05924*P08+0.0275824*P09-0.00920199*P10 -0.000278785*P11, where K_pr(gastro) is a coefficient of assessing the effectiveness of eliminating gastroenterological symptoms; P01 – duration of diet compliance in months; P02 is gender, denoted by 1 for boys, number 2 for girls; P03 – age, number of full years; P04 is growth in centimeters; P05 is weight in kilograms; P06 is body weight index, unit units; P07 is the level of iron in the serum of venous blood, mmol/l; P08 is the serum level of venous blood, mmol/l; P09 – availability of marker HLA DQ2/DQ8, zero is absent, unit is detected; P10 – level of antibodies of class G to gliadin, unit/ml; P11 is level of antibodies of A class to deamidated gliadin peptides, unit/ml. If value of prediction coefficient is more than 0.65 conv. units, gluten-free diet is recommended; if value of prediction coefficient is 0.65 conv. units and less, gluten-free diet compliance is judged to be ineffective.

EFFECT: use of the method enables prediction taking into account the initial level of individual indicators of the nutritional status and genetic markers for prescribing a diet therapy for the purpose of correcting gastroenterological disorders.

1 cl, 2 ex