METHOD FOR PREDICTING THE RISK OF DEVELOPING SUBCLINICAL LEFT VENTRICULAR SYSTOLIC DYSFUNCTION IN THE PATIENTS WITH CHRONIC LYMPHATIC LEUKEMIA IN THE CHEMOTHERAPY IN THE FCR MODE Russian patent published in 2020 - IPC A61B8/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to cardiology. Before and after 3 courses of FCR chemotherapy, a speckle-tracking echocardiography is performed to determine the global longitudinal deformation of GLS. That is followed by 3 courses of chemotherapy, stress echocardiography with dobutamine to determine contractile reserve by GLS. Field of the risk of developing subclinical left ventricular systolic dysfunction is evaluated: with GLS reduction ≤ 15 % relative to initial value and absence of contractile reserve, development risk is high. When reducing GLS ≤ 15 % of the initial value and presence of contractile reserve, development risk is low. When reducing GLS > 15 % of the initial value, the development of subclinical left ventricular systolic dysfunction is diagnosed.

EFFECT: method enables high-accuracy prediction of subclinical left ventricular dysfunction in the use of a cardiotoxic preparation, clearly determining an algorithm of study frequency and interpretation thereof.

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