FIELD: pharmaceutics.
SUBSTANCE: invention relates to pharmaceutics and represents a method for preparing a pharmaceutical composition, comprising the fact that the active substance is presented in the form of microparticles, for formation of which D,L-lactide-co-glycolide and polyvinyl alcohol are used, and active substance together with D,L-lactide-co-glycolide containing poly-D,L-lactic and polyglycolic acids in molar ratio of 50:50, is dissolved in chloroform, obtained solution is introduced into 3 % aqueous solution of polyvinyl alcohol with constant stirring with the help of homogeniser at rate of 20,000 rpm, followed by washing and separation by centrifugation of formed microparticles with particle size of 300±50 nm, characterized in that cinnarizine is used as the active substance, and lyophilic drying is used to obtain the final substance.
EFFECT: composition obtained by said method releases the active substance for a longer period of time with the rate required for manifestation of pharmacological action.
1 cl, 2 dwg, 1 tbl, 2 ex
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Authors
Dates
2020-07-28—Published
2019-12-17—Filed