METHOD FOR PREPARING PHARMACEUTICAL COMPOSITION CONTAINING ALPRAZOLAM Russian patent published in 2015 - IPC A61K9/50 A61K31/5517 A61K47/30 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, and can be used to prepare a prolonged dosage form of alprazolam. A composition contains microcapsules consisting of alprazolam, a suitable pharmaceutical carrier and a polymer matrix. A method of preparing a prolonged dosage form of alprazolam for parenteral use on the basis of poly-D,L-lactide-co-glycolide provides for preparing a primary emulsion by dissolving an active substances and an additive agent in a small volume of chloroform followed by introducing the prepared solution into an aqueous surfactant at constant stirring in a homogeniser at 20,000 rpm. Thereafter, chloroform is completely removed from the prepared primary emulsion for 24 hours; the prepared microcapsules are washed and separated by centrifugation. They are shaken with purified water to prepare the final suspension.

EFFECT: prepared composition releases the active substance for a longer period of time at a rate required to show the pharmacological action.

1 tbl