DITRA MODELS IN NON-HUMAN ANIMALS AND THEIR USE Russian patent published in 2023 - IPC A01K67/27 C07K14/54 C07K14/715 C12N15/85 

FIELD: biotechnology.

SUBSTANCE: invention relates to a genetically modified rodent, the genome of which contains a humanized Il1rl2 gene functionally linked to the endogenous rodent Il1rl2 promoter in the endogenous Il1rl2 locus of the rodent, the human IL1F6 gene in the endogenous Il1f6 locus of the rodent, the human IL1F8 gene in the endogenous Il1f locus 8 rodent and the human IL1F9 gene in the endogenous rodent Il1f9 locus, to its cell and tissue, as well as to a method of its production. Also the following is disclosed: a targeting nucleic acid construct for generating a humanized Il1rl2 gene in the rodent genome and a targeting nucleic acid construct for integrating the human IL1F6 gene, the human IL1F8 type, and the human IL1F9 gene into the rodent genome.

EFFECT: invention is effective for evaluating the therapeutic efficacy of a candidate compound for the treatment of a disease associated with dysregulation of IL-36 signaling.

45 cl, 9 dwg, 6 tbl, 2 ex