FIELD: immunology.
SUBSTANCE: disclosed is a T cell comprising a chimeric antigen receptor (CAR) and a chimeric costimulatory receptor (CCR), as well as a method of producing said cell. There are described methods of inducing tumor cell death, treating and preventing neoplasm, a pharmaceutical composition and a kit for immunotherapy.
EFFECT: chimeric costimulatory receptor binding with antigen provides costimulatory signal delivery to T-cell that provides higher degree of cytolytic activity.
51 cl, 6 dwg, 1 tbl, 1 ex
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