FIELD: biochemistry.
SUBSTANCE: present invention relates to a method of forming a cross-linked electron-active hydrophilic copolymer, a homogeneous, isotropic, electron-active, hydrophilic copolymer and a solution of comonomers, used for its production. Method comprises the following steps: providing a comonomer solution containing at least one hydrophobic monomer, at least one hydrophilic monomer, water, at least one amino acid and at least one cross-linking agent; and polymerisation of said solution of comonomers. Hydrophilic monomer is selected from methacrylic acid, 2-hydroxyethyl methacrylate, ethyl acrylate, vinylpyrrolidone, methyl ether of acrylic acid, monomethacryloyloxyethyl phthalate, ammonium sulphatoethylmethacrylate, polyvinyl alcohol or a combination thereof. Hydrophobic monomer is selected from methyl methacrylate, allyl methacrylate, acrylonitrile, methacryloxypropyltris(trimethylsiloxy)silane, 2,2,2-trifluoroethyl methacrylate or combinations thereof. At least one amino acid is selected from phenylalanine, tryptophan, histidine, ethylenediaminetetraacetic acid (EDTA) and tyrosine or a combination thereof.
EFFECT: obtained electronically active cross-linked hydrophilic copolymer is suitable for use in biomedical purposes due to its biological acceptability, hydrophilic properties, flexibility and resistance to chemical degradation.
18 cl, 9 dwg, 4 tbl, 6 ex
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Authors
Dates
2020-08-11—Published
2016-11-30—Filed