VACCINATION WITH REPLICON PARTICLES AND OIL ADJUVANT Russian patent published in 2023 - IPC A61K39/193 

FIELD: biotechnology; veterinary medicine.

SUBSTANCE: vaccine against a pathogen that causes disease in an animal is proposed. The vaccine contains an immunologically effective amount of alphavirus RNA-replicon particles encoding an antigen derived from an animal pathogen. The vaccine also contains an oil adjuvant. The oil adjuvant contains mineral oil, which is liquid paraffin oil, and non-mineral oil, which is the acetate form of Vitamin E. A kit for immunizing an animal is proposed. The kit contains two containers, one container with a Venezuelan equine encephalitis (VEE) alphavirus RNA-replicon particle encoding an antigen derived from an animal pathogen, and one container with an oil adjuvant. The oil adjuvant contains mineral oil, which is a liquid paraffin oil, and non-mineral oil, which is the acetate form of Vitamin E. A method for immunizing an animal using the specified vaccine and using an RNA-replicon particle of the alphavirus of Venezuelan equine encephalitis (VEE), encoding an antigen derived from an animal pathogen, in a method for immunizing an animal.

EFFECT: effective immunization of animals against various diseases.

13 cl, 10 tbl, 11 dwg, 8 ex