METHOD OF PRODUCING CRYSTALLINE FORM OF MNK INHIBITORS Russian patent published in 2024 - IPC C07D471/04 A61K31/506 A61K47/02 A61K47/12 A61K47/20 A61K47/38 A61P35/00 A61P35/02 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing a crystalline solid compound 6'-((6-aminopyrimidin-4-yl)amino)-8'-methyl-2'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione, having structure (I), where the crystalline solid compound has an X-ray powder diffraction pattern with characteristic peaks expressed in degrees 2θ ± 0.2, at 8.07; 10.81; 14.68 and 22.07. Method is carried out by (a) forming suspension 6'-((6-aminopyrimidin-4-yl)amino)-8'-methyl-2'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione in aqueous ethanol at temperature of 35 to 45 °C, (b) cooling the suspension to room temperature, (c) filtering the suspension to separate the compacted solid precipitate, (d) washing the pressed sediment with aqueous ethanol and (e) drying the pressed sediment under vacuum to constant weight.

EFFECT: obtaining a thermodynamically stable polymorphic form of 6'-((6-aminopyrimidin-4-yl)amino)-8'-methyl-2'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione.

4 cl, 5 tbl, 4 dwg, 1 ex