FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing 3-[1,2,3,6-tetrahydropyridin-2-yl]pyridine glutarate. Method of producing glutarate 3-[1,2,3,6-tetrahydropyridin-2-yl]pyridine, with ratio of 3-[1,2,3,6-tetrahydropyridin-2-yl]pyridine to glutarate 1:1, includes steps of obtaining solution containing 3-[1,2,3,6-tetrahydropyridin-2-yl]pyridine, glutaric acid and a solvent; heating obtained solution; providing formation of salt of 3-[1,2,3,6-tetrahydropyridin-2-yl]pyridine with glutaric acid and extraction of salt of 3-[1,2,3,6-tetrahydropyridin-2-yl]pyridine of glutaric acid, where said solvent used to obtain solution of 3-[1,2,3,6-tetrahydropyridin-2-yl]pyridine, glutaric acid and the solvent is acetonitrile. Obtained 3-[1,2,3,6-tetrahydropyridin-2-yl]pyridine glutarate is in a polymorphic form which has an X-ray powder diffraction pattern (CuKα), containing three or more peaks selected from 8.0 ± 0.2°2θ, 11.0 ± 0.2°2θ, 13.3 ± 0.2°2θ, 16.5 ± 0.2°2θ, 18.0 ± 0.2°2θ, 20.7 ± 0.2°2θ, 21.0 ± 0.2°2θ, 21.4 ± 0.2°2θ, 22.0 ± 0.2°2θ, 22.3 ± 0.2°2θ, 23.3 ± 0.2°2θ and 24.5 ± 0.2°2θ.
EFFECT: obtaining anatabine glutarate, having such properties as high degree of crystallinity, storage stability, low level of hygroscopicity, fluidity.
5 cl, 1 tbl, 14 dwg, 6 ex
