FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine, namely, to medicinal products for combating infections caused by gram-negative bacteria. Bactericidal pharmaceutical composition for topical application in the form of a gel has the following composition, % wt.: recombinant modified endolysin LysECD7-SMAP 0.2 to 1 %, Hydroxyethyl Cellulose 1 %, Polyethylene Glycol 1500 (PEG 1500) 1.5 %, phosphate buffer solution with a pH=7.5 96,5 to 97,3 %. Above composition is applied as an antimicrobial agent against sensitive bacterial species Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, Achromobacter spp, Burkholderia cepacia complex, Enterobacter spp, Staphylococcus aureus, and Listeria monocytogenes.
EFFECT: bactericidal composition has a pronounced specific pharmacological (antibacterial) activity against gram-negative bacteria on topical application, including bacteria with multiple drug resistance, and is capable of cleaning a wound due to the outflow of the purulent contents.
2 cl, 2 dwg, 1 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| BACTERICIDAL PHARMACEUTICAL COMPOSITION FOR PARENTERAL USE IN THE FORM OF LYOPHILIZATE WITH ENDOLYSIN | 2021 |
|
RU2792679C1 |
| MODIFIED ENDOLYSIN AND ANTIBACTERIAL COMPOSITIONS BASED THEREON FOR TREATING INFECTIONS CAUSED BY ACINETOBACTER BAUMANNII, PSEUDOMONAS AERUGINOSA, KLEBSIELLA PNEUMONIAE, ESCHERICHIA COLI BACTERIA | 2023 |
|
RU2813626C1 |
| ANTIBACTERIAL COMPOSITION (EMBODIMENTS) AND USE OF PROTEIN AS ANTIMICROBIAL AGENT DIRECTED AGAINST GRAM-NEGATIVE BACTERIA: PSEUDOMONAS AERUGINOSA, ACINETOBACTER BAUMANNII, KLEBSIELLA PNEUMONIAE AND SALMONELLA TYPHI (EMBODIMENTS) | 2019 |
|
RU2730615C1 |
| ANTIBACTERIAL COMPOSITION BASED ON ENDOLYSINS AND DRUGS IN FORM OF GEL OR SPRAY, USING IT | 2021 |
|
RU2790481C1 |
| ANTIBACTERIAL COMPOSITION (EMBODIMENTS) AND USE OF PROTEIN AS ANTIMICROBIAL AGENT DIRECTED AGAINST BACTERIA PSEUDOMONAS AERUGINOSA, KLEBSIELLA PNEUMONIAE, ESCHERICHIA COLI, SALMONELLA TYPHI AND STAPHYLOCOCCUS HAEMOLYTICUS (EMBODIMENTS) | 2019 |
|
RU2730613C1 |
| ANTIBACTERIAL COMPOSITION (EMBODIMENTS) AND USE OF PROTEIN AS ANTIMICROBIAL AGENT DIRECTED AGAINST BACTERIA PSEUDOMONAS AERUGINOSA, KLEBSIELLA PNEUMONIAE, ESCHERICHIA COLI, SALMONELLA TYPHI AND STAPHYLOCOCCUS HAEMOLYTICUS (EMBODIMENTS) | 2019 |
|
RU2730614C1 |
| ANTIBACTERIAL COMPOSITION (EMBODIMENTS) AND USE OF PROTEIN AS AN ANTIMICROBIAL AGENT DIRECTED AGAINST ACINETOBACTER BAUMANNII BACTERIA, (EMBODIMENTS) | 2019 |
|
RU2730616C1 |
| LYSINE POLYPEPTIDES ACTIVE AGAINST GRAM-NEGATIVE BACTERIA | 2016 |
|
RU2724545C2 |
| ALGINATE OLIGOMERS APPLICABLE IN OVERCOMING MULTIPLE DRUG RESISTANCE IN BACTERIA | 2010 |
|
RU2582938C2 |
| PREPARATION FOR TREATING INFECTIOUS DISEASES CAUSED BY MULTIRESISTANT BACTERIA | 2006 |
|
RU2377985C2 |
