FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, specifically to production of antibacterial recombinant proteins, and can be used in medicine as an antibacterial composition exhibiting activity against gram-negative bacteria Pseudomonas aeruginosa. A recombinant protein is obtained, which is covalently cross-linked endolysin of the antipseudomonal bacteriophage KRR10 and a modified fragment [K2,7,13]-SMAP-29(1-17) of myeloid antimicrobial sheep peptide SMAP-29.
EFFECT: invention provides higher effectiveness of antibacterial therapy against Pseudomonas aeruginosa bacteria.
2 cl, 7 dwg, 1 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANTIBACTERIAL COMPOSITION (EMBODIMENTS) AND USE OF PROTEIN AS ANTIMICROBIAL AGENT DIRECTED AGAINST GRAM-NEGATIVE BACTERIA: PSEUDOMONAS AERUGINOSA, ACINETOBACTER BAUMANNII, KLEBSIELLA PNEUMONIAE AND SALMONELLA TYPHI (EMBODIMENTS) | 2019 |
|
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| ANTIBACTERIAL COMPOSITION (EMBODIMENTS) AND USE OF PROTEIN AS AN ANTIMICROBIAL AGENT DIRECTED AGAINST ACINETOBACTER BAUMANNII BACTERIA, (EMBODIMENTS) | 2019 |
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|
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