NUCLEOSIDE DERIVATIVES OF 1,3-DIAZA-2-OXOPHENOXAZINE AS HERPESVIRUS REPLICATION INHIBITORS Russian patent published in 2020 - IPC A61K31/7042 C07H19/24 C07H19/02 C07D498/12 A61K31/5383 A61P31/22 

FIELD: chemistry; medicine.

SUBSTANCE: invention relates to use of 1,3-diaza-2-oxophenoxazine derivatives of formulas (1), (2) and (3) in medicine as herpes virus recurrence inhibitors. Disclosed is use of derivatives of formulas (1), (2) and (3):

, ,

where R¹ is H, R² is H and R³ is H; or R¹ is H, R² is H and R³ is OCH₃; or R¹ is H, R² is DMTr and R³ is H; or R¹ is H, R² is DMTr and R³ is OH; or R¹ is H, R² is DMTr and R³ is OCH; or R¹ is OCH₂CH₂NH₂, R² is H and R³ is H; or R¹ is OCH₂CH₂NH₂, R² is H and R³ is OH; or R¹ is OCH₂CH₂NH-CBz, R² is DMTr and R³ is OH; or R¹ is OCH₂CH₂NH₂, R² is DMTr and R³ is H as herpes virus inhibitors, including varicella-zoster virus and cytomegalovirus.

EFFECT: novel use of said derivatives effective as herpesvirus reproduction inhibitors, including varicella zoster virus and cytomegalovirus.

2 cl, 1 tbl, 21 ex, 3 dwg