FIELD: chemistry; medicine.
SUBSTANCE: invention relates to use of 1,3-diaza-2-oxophenoxazine derivatives of formulas (1), (2) and (3) in medicine as herpes virus recurrence inhibitors. Disclosed is use of derivatives of formulas (1), (2) and (3):
,
,
where R1 is H, R2 is H and R3 is H; or R1 is H, R2 is H and R3 is OCH3; or R1 is H, R2 is DMTr and R3 is H; or R1 is H, R2 is DMTr and R3 is OH; or R1 is H, R2 is DMTr and R3 is OCH; or R1 is OCH2CH2NH2, R2 is H and R3 is H; or R1 is OCH2CH2NH2, R2 is H and R3 is OH; or R1 is OCH2CH2NH-CBz, R2 is DMTr and R3 is OH; or R1 is OCH2CH2NH2, R2 is DMTr and R3 is H as herpes virus inhibitors, including varicella-zoster virus and cytomegalovirus.
EFFECT: novel use of said derivatives effective as herpesvirus reproduction inhibitors, including varicella zoster virus and cytomegalovirus.
2 cl, 1 tbl, 21 ex, 3 dwg
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Authors
Dates
2020-09-02—Published
2019-04-26—Filed