OPHTHALMIC COMPOSITIONS CONTAINING COOPERATIVE COMPLEXES OF LOW- AND HIGH-MOLECULAR HYALURONIC ACID Russian patent published in 2020 - IPC A61K31/726 A61K31/728 A61P27/02 A61P27/04 

FIELD: medicine.

SUBSTANCE: present invention relates to an ophthalmic composition containing an aqueous base and, as active ingredients, cooperative hybrid complexes, called L/H-HA, between at least one fraction (L-HA) of hyaluronic acid or chondroitin sulphate, keratan sulphate or chondroitin (CS, KS, C), wherein said fraction has average molecular weight in range of 1·10⁴ to 5·10⁵ Da, and at least one hyaluronic acid fraction (H-Ha), having average molecular weight of at least 5 times higher than the average molecular weight of L-HA and in any case in range of 5×10⁴ to 5×10⁶ Da, wherein the weight ratio of L-HA to H-HA in the L/H-HA complex is in range of 0.5 to 2.

EFFECT: present invention enables to obtain compositions, which have improved moisturizing and lubricating action, as well as in contact with eye surface, compositions containing L/H-HA complexes, act as L-HA and H-HA systems with slow release, ensuring high mucoadhesion.

9 cl, 8 ex, 5 tbl