FIELD: immunology; medicine.
SUBSTANCE: invention is related in particular to a complex intended for use in the prevention and/or treatment of cancer, wherein the complex contains a) a cell-penetrating peptide, b) at least three antigenic epitopes and c) at least one peptide agonist TLR, in which components a)-c) are covalently linked. In particular, compositions are described for use in the prevention and/or treatment of colorectal cancer, such as pharmaceutical compositions and vaccines.
EFFECT: present invention makes it possible to obtain a new complex for use in immunotherapy of colorectal cancer, which is a more effective vaccine, primarily an anti-cancer vaccine, which has improved antitumor activity, intended for the prevention and/or treatment of colorectal cancer.
47 cl, 76 dwg, 46 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PEPTIDE VACCINES AGAINST INTERLEUKIN-31 | 2019 |
|
RU2786441C2 |
| IMPROVED IMMUNOGENICITY OF L2 HPV PEPTIDE | 2017 |
|
RU2743016C2 |
| PREPARATION CONTAINING VIII FACTOR AND VON WILLEBRAND FACTOR PEPTIDES | 2015 |
|
RU2714154C2 |
| T-CELL RECEPTOR CONSTRUCTS AND THEIR USE | 2019 |
|
RU2785954C2 |
| ANTIGENS AND ANTIGEN COMPOSITIONS | 2013 |
|
RU2727476C2 |
| EXPRESSION OF NITROGENASE POLYPEPTIDES IN PLANT CELLS | 2018 |
|
RU2809244C2 |
| THERAPEUTIC ANTI-CANCER NEOEPITOPE VACCINE | 2017 |
|
RU2782422C2 |
| NOVEL ANTIBODIES TO BSSL | 2020 |
|
RU2826992C2 |
| TAU-PEPTIDE IMMUNOGENIC CONSTRUCTS | 2018 |
|
RU2798972C2 |
| ADAM9-BINDING MOLECULES AND THEIR APPLICATION METHODS | 2017 |
|
RU2783619C2 |
