FIELD: medicine.
SUBSTANCE: invention relates to a method for identifying at least one glycoform and/or transferrin isoform in various types of complex biological media. To this end, the analyzed biological fluid is brought into contact with lanthanide 3+ ion source. Obtained derivatives of carbohydrate-deficient transferrin with lanthanide ions 3+ are analyzed by HPLC or CE using a fluorescent detector.
EFFECT: invention provides a reliable and sensitive method of determining carbohydrate-deficient transferrin in blood serum, blood plasma, in cerebrospinal fluid, vitreous fluid or saliva for diagnosing the clinical/toxicological state of the patient.
15 cl, 3 dwg, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DIAGNOSTIC TECHNIQUE FOR ALCOHOL ABUSE | 2010 |
|
RU2461832C2 |
| METHOD FOR PRODUCING SIALIC ACID-CONTAINING SUGAR CHAIN | 2012 |
|
RU2597975C2 |
| GLYCOSYLATED POLYPEPTIDE AND ITS PHARMACEUTICAL COMPOSITION | 2012 |
|
RU2636456C2 |
| GLYCOFORMS OF VII FACTOR | 2001 |
|
RU2325181C2 |
| METHOD FOR PREPARING RECOMBINANT HUMAN ERYTHROPOIETIN AND PREPARED ERYTHROPOIETIN, PHARMACEUTICAL COMPOSITION | 1999 |
|
RU2215748C2 |
| CONJUGATE OF FACTOR VII POLYPEPTIDE, METHOD OF OBTAINING IT, ITS APPLICATION AND PHARMACEUTICAL COMPOSITION CONTAINING IT | 2003 |
|
RU2362807C2 |
| TREATMENT OF α-GALACTOSIDASE A INSUFFICIENCY | 2000 |
|
RU2248213C2 |
| GLP-1 PEPTIDE HAVING ATTACHED OLIGOSACCHARIDE CHAIN | 2008 |
|
RU2539829C2 |
| GLYCOSYLATED POLYPEPTIDES AND MEDICINAL COMPOSITIONS CONTAINING THESE POLYPEPTIDES | 2012 |
|
RU2627184C2 |
| GLYCOSYLATED POLYPEPTIDES AND MEDICINAL COMPOSITIONS CONTAINING THESE POLYPEPTIDES | 2012 |
|
RU2624034C2 |
