FIELD: organic chemistry.
SUBSTANCE: invention relates to a method of producing a compound of formula (I), comprising a step of reacting a compound of formula VII with a base, which is lithium bis(trimethylsilyl)amide, in the presence of a lithium halide, where LG denotes a leaving group, wherein the method is carried out in an aprotic inert solvent at temperature of −100 °C to 0 °C.
EFFECT: method of producing a compound of formula (I), characterized by high output and purity of the desired compound.
9 cl, 1 tbl, 2 ex
Title | Year | Author | Number |
---|---|---|---|
METHODS FOR OBTAINING CYTOTOXIC BENZODIAZEPINE DERIVATIVES | 2019 |
|
RU2807546C2 |
OBTAINING INTERMEDIATE PRODUCTS FOR SYNTHESIS OF POSACONAZOLE | 2011 |
|
RU2580318C2 |
METHOD OF NEBIVOLOL RACEMATE OBTAINMENT | 2006 |
|
RU2392277C2 |
DERIVATIVES OF CARBOXYLIC ACIDS WITH OXAZOLE[5,4-b]PYRIDINE RING | 2012 |
|
RU2609002C2 |
METHOD OF PRODUCING CHIRAL TRIAZOLONES | 2011 |
|
RU2585760C2 |
METHOD FOR PRODUCING SUBSTITUTED 3-PYRIDYLMETHYL AMMONIUM BROMIDES | 2009 |
|
RU2549896C2 |
METHOD OF PRODUCING DIARYL CYCLOALKYL DERIVATIVES | 2005 |
|
RU2414459C2 |
METHOD OF PRODUCING COMPOUND USED AS TAFIa INHIBITOR | 2010 |
|
RU2538506C2 |
DERIVATIVES OF CARBOXYLIC ACIDS WITH OXAZOLE[4,5-c]PYRIDINE CYCLE | 2012 |
|
RU2609004C2 |
METHODS AND COMPOUNDS THAT CAN BE USED TO SYNTHESIZE OREXIN-2 RECEPTORS ANTAGONISTS | 2013 |
|
RU2617696C2 |
Authors
Dates
2020-10-23—Published
2016-01-28—Filed