METHOD OF PRODUCING 4-THIA-2,6-DIAZABICYCLO[6_3_1]{[6_2_2]}-DODECA-1(12{10}),8,10{11}-TRIEN-7-ONES Russian patent published in 2020 - IPC C07D285/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing 4-thia-2,6-diazabicyclo[6.3.1]{[6.2.2]}-dodeca-1(12{10}),8,10{11}-trien-7-ones of general formula (1). Method comprises reacting meta- or para-aminobenzamide with N,N,N',N'-tetramethylmethanediamine and Na₂S⋅9H₂O in presence of RbNO₃ catalyst, taken in molar ratio aminobenzamide : N,N,N',N'-tetramethylmethanediamine : Na₂S⋅9H₂O : [cat] = 10 : (15–25) : 10 : (1–3), at temperature of 60–80 °C for 7.5–8.5 hours in a mixture of chloroform: ethanol = 1:1 as a solvent.

EFFECT: prepared according to the method of the compound of formula (1) are promising for making preparations for treating central and peripheral nervous system diseases and abstinence caused by cessation of chemical abuse.

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