TRANSCUTANEOUS PATCH WITH MICRONEEDLES CONTAINING DONEPEZIL Russian patent published in 2020 - IPC A61K9/70 A61K9/00 A61K31/445 A61K47/36 A61M31/00 A61M37/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a composition for producing a microneedle, a soluble microneedle and a transcutaneous patch with microneedles comprising a soluble microneedle. Composition for producing the microneedle contains donepezil or a pharmaceutically acceptable salt thereof and hyaluronic acid or a pharmaceutically acceptable salt thereof, where the weight ratio of donepezil or its pharmaceutically acceptable salt and hyaluronic acid or its pharmaceutically acceptable salt ranges from 1:1.5 to 1:2.9.

EFFECT: technical result is obtaining a soluble microneedle contained in a transcutaneous patch with microneedles, having high capacity of drug loading and excellent strength, thus containing an effective amount of donepezil or its pharmaceutically acceptable salt even with a small area of microneedle, wherein the transcutaneous patch provides a low level of skin irritation.

15 cl, 4 ex, 7 tbl, 8 dwg