TEST MODEL FOR INVESTIGATING ACTION OF DRUGS WHICH PREVENT DEMYELINATION, METHOD FOR PREPARING AND USING THEREOF Russian patent published in 2020 - IPC G01N33/48 

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, namely to neurology, and biotechnology. Disclosed is a test model for investigating the effect of drugs on multiple sclerosis in vitro, characterized by that it represents a primary oligodendrocyte culture obtained by explant method, by placing freshly excised cerebellar fragments of newborn rats on glass cover glasses in petri dishes with base diameter of 35 mm, wherein the coverslips are coated with a substrate providing attachment, spreading and movement of cultured cells, and top layer of nutrient medium providing growth of cultured cells is arranged. Also disclosed is a method of producing said test model and a method of investigating the action of drug preparations using said test model.

EFFECT: group of inventions provides a simple test model which enables to conduct drug testing on a large number of samples of myelin-forming oligodendrocyte culture with statistical validity p < 0_05.

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