METHOD FOR INDUCTION OF AN ABSCOPAL ANTITUMOR EFFECT IN THE EXPERIMENTAL MODEL OF EHRLICH'S CARCINOMA Russian patent published in 2020 - IPC A61B6/00 G09B23/28 A61N5/10 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to experimental oncology, and can be used for inducing an abscopal anti-tumor effect in an experimental Ehrlich's carcinoma model. It is followed by subcutaneous bilateral transplantation of ascitic Ehrlich's carcinoma in mice, formation of tumor contralateral nodes on lower extremities and subsequent local irradiation of one of tumor nodes. In 5 days after single-stage bilateral transplantation of tumor and formation of tumor nodes from both sides, local single irradiation of one of tumor nodes is performed ⁶⁰Co γ-beams in dose of 30 Gy, without preliminary stimulation of animals immunity.

EFFECT: method provides creating an experimental model for implementing an abscopal effect on a distant tumor without using additional inductors by selecting optimal doses and modes of radiation therapy, which leads to systemic activation of immune-mediated anti-tumor response, including to distant metastatic tumor centers.

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