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2 837 550

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IPC

A61K31/155(2006-01-01)

A61P13/10(2006-01-01)

(21) (22)

Application

2024119394, 2024-07-11

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Start date

2024-07-11

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Actual filing date

2024-07-11

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Published

2025-04-01

(72)

Inventor

Filimonova Marina VladimirovnaKosachenko Aleksandr OlegovichFilimonov Aleksandr SergeevichRybachuk Vitalii AleksandrovichNikolaev Kirill AnatolevichShevchenko Liudmila IvanovnaShegai Petr ViktorovichKaprin Andrei Dmitrievich

(73)

Holder

Federalnoe Gosudarstvennoe Biudzhetnoe Uchrezhdenie Meditsinskii Issledovatelskii Tsentr Radiologii" Ministerstva Zdravookhraneniia Rossiiskoi Federatsii Radiologii" Minzdrava Rossii)

METHOD FOR PHARMACOLOGICAL PREVENTION OF RADIATION-INDUCED CYSTITIS AND BLADDER FIBROSIS Russian patent published in 2025 - IPC A61K31/155 A61P13/10

Abstract RU 2837550 C2

FIELD: pharmaceutics.

SUBSTANCE: invention refers to pharmaceutics, namely to a method for pharmacological prevention of radiation-induced cystitis and bladder fibrosis. A method for pharmacological prevention of radiation-induced cystitis and bladder fibrosis involves preventive introduction of 1-isobutanoyl-2-isopropylisothiourea 30 minutes before irradiation in doses for mice and rats intragastrically 150-225 mg/kg.

EFFECT: invention enables providing clinically and morphologically evident prevention of early and late radiation cystitis and fibrosis of the bladder using a safe method with low risk of negative effects.

2 cl, 11 dwg, 3 ex

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RU 2 837 550 C2

Authors

Filimonova Marina Vladimirovna

Kosachenko Aleksandr Olegovich

Filimonov Aleksandr Sergeevich

Rybachuk Vitalii Aleksandrovich

Nikolaev Kirill Anatolevich

Shevchenko Liudmila Ivanovna

Shegai Petr Viktorovich

Kaprin Andrei Dmitrievich

Dates

2025-04-01—Published

2024-07-11—Filed