METHOD OF PROTON THERAPY FOR SOLID EHRLICH CARCINOMA Russian patent published in 2023 - IPC A61N5/00 A61K33/245 A61P35/00 

FIELD: medicine; oncology; radiation therapy.

SUBSTANCE: invention can be used in proton therapy for solid Ehrlich carcinoma. The method involves the introduction of nanoparticles as a radiosensitizer, after which the tumor is irradiated with proton beams at a dose of 10 Gy or 31 Gy. 15 minutes before irradiation with proton beams, bismuth nanoparticles coated with Pluronic-F 127 in an amount of 1.5 mg/mouse are injected intratumorally in the form of 100 μl of a 1.5% suspension based on phosphate-buffered saline or bismuth nanoparticles coated with polyethylene glycol in an amount of 1.5 mg/mouse in the form of 100 μl of a 1.5% suspension based on phosphate-buffered saline, after which the tumor is irradiated with proton beams at a clinically acceptable dose rate of 30 Gy/h.

EFFECT: use of the invention makes it possible to increase the safety of exposure to proton radiation through the use of a clinically acceptable dose rate in combination with the preliminary introduction of metal nanoparticles while simultaneously ensuring high efficiency of exposure.

1 cl, 4 dwg, 2 ex