FIELD: chemical or physical processes.
SUBSTANCE: invention relates to versions of a method of producing a compound of formula [I], or a hydrate thereof, which can be used as inhibitors of pyruvate dehydrogenase. In one version, the method includes a step of converting a compound of formula [II], or a methanol solvate thereof, into a compound, represented by formula [IV], a coupling reaction with a compound of formula [III], in the presence of a palladium catalyst, an alkali metal carbonate and a carboxylic acid; a step for hydrolysis of the compound of formula [IV] described above to convert it into a compound represented by formula [V] and a step for reacting the compound of formula [V] described above with ammonia in the presence of a condensing agent. Invention also relates to intermediate compounds of formulas [IV], [II], [IIm], [III] and to a method of producing a compound of formula [IV].
EFFECT: disclosed is a method of producing a pyrazolamide compound.
13 cl, 1 ex
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|
RU2538963C2 |
| 3,5-DISUBSTITUTED ALKYNYLBENZENE COMPOUND AND SALT THEREOF | 2013 |
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RU2576384C1 |
| PYRAZOLE-AMIDE COMPOUND AND MEDICINAL USES THEREFOR | 2014 |
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RU2664532C2 |
| QUINOLYL PYRROLE PYRIMIDYL CONDENSED COMPOUND OR SALT THEREOF | 2013 |
|
RU2581039C1 |
| BENZOPYRROLE DERIVATIVES CONTAINING HEXAHYDROPYRIDINE CYCLE | 2005 |
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RU2332413C1 |
| AZOLE-SUBSTITUTED PYRIDINE COMPOUND | 2017 |
|
RU2730498C2 |
| NEW CYANOPYRIMIDINE DERIVATIVE | 2010 |
|
RU2533115C2 |
| BENZOXAZOLE DERIVATIVE, MEDICINAL AGENT BASED ON THEREOF AND METHOD OF TREATMENT OF IRRITABLE BOWEL SYNDROME STATE OR FUNCTIONAL GASTRO- ENTERIC TRACT DISTURBANCE | 1999 |
|
RU2204558C2 |
| RUBBER COMPOSITION | 2012 |
|
RU2605122C2 |
| ANTI-Helicobacter pylori AGENT, INHIBITING GASTRIC JUICE SECRETION | 2007 |
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RU2451682C2 |
