METHOD Russian patent published in 2020 - IPC A61K39/395 A61P35/00 G01N33/574 

FIELD: medicine; oncology; immunology.

SUBSTANCE: group of inventions is intended for identification of cancer patient, which is suitable for treatment using control immune points, as well as to methods of treating such individuals. A method of identifying an individual suffering an oncological disease, which is suitable for treating by exposing control immune points, where the method involves: (i) determining the number of clonal neoantigens in one or more malignant cells of said individual; and/or (ii) determining a relation of clonal: subclonal neoantigens and/or a fraction of subclonal neoantigens in more than one malignant cell of said individual. Higher than the median number of clonal neoantigens, and/or higher than the median ratio of clonal: subclonal neoantigens, or lower than the median, fraction of subclonal neoantigens as compared to control group of oncological patients is an indicator of response to treatment by exposure to control immune points. For the treatment or prevention of oncological disease in an individual, the following steps are carried out: i) identification of the individual suffering from oncological disease, which is suitable for treating by exposing the control immune points by the above method; and ii) treating said individual by exposing control immune points.

EFFECT: using the group of inventions enables to increase the effectiveness of treatment of an individual with cancer.

28 cl, 12 dwg, 3 tbl, 1 ex