FIELD: biotechnology.
SUBSTANCE: present invention relates to the field of biotechnology, in particular to new polypeptide for therapy of different tumor diseases; it can be used in medicine. The invention allows for obtaining polypeptide containing at least four different tumor-specific neoantigens fused with at least one amino acid sequence of T-cell amplifier. Compositions containing, in a mixture of separately, a vaccine containing therapeutic polypeptide, a vector or a collection of vectors, according to the present invention, and at least one modulator of a molecule, which is a control point, or an immunomodulator of another type for use in the treatment of cancer, are disclosed.
EFFECT: obtaining compositions for the treatment of cancer.
18 cl, 5 ex, 3 tbl, 8 dwg
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