METHOD OF PRODUCING ENZYMATICALLY RESISTANT COLLAGEN MATERIALS Russian patent published in 2020 - IPC A61L27/24 A61F2/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: group of inventions relates to pharmaceutics, medicine and bioorganic chemistry. Disclosed is a method of producing collagen material cross-linked by carbodiimide resistant to enzymatic degradation by collagenases, comprising a step of deamidation of side groups of asparagine residues and glutamine in collagen alpha chains by treating the initial collagen-containing material with an aqueous solution of lithium hydroxide, potassium or sodium in concentration of 0.3 m to concentration of saturated solution at temperature from 0 to 45 °C for 8–168 hours, washing the obtained deamidated collagen material obtained from the previous step from the aqueous alkali metal hydroxide solution; and a subsequent step of crosslinking deamidated collagen material with a carbodiimide in an aqueous, aqueous-organic or organic medium. Also disclosed is a product for implantation in body tissues obtained by said method.

EFFECT: group of inventions provides producing cross-linked collagen materials which are resistant to enzymatic degradation by collagenases.

10 cl, 10 dwg, 2 tbl, 1 ex