INJECTION HETEROGENIC BIOPOLYMER HYDROGEL FOR SUBSTITUTIONAL AND REGENERATIVE SURGERY AND METHOD OF ITS OBTAINING Russian patent published in 2011 - IPC A61K35/12 A61K38/39 

FIELD: medicine.

SUBSTANCE: injection heterogeneous elastically-resilient biodegradable biopolymer hydrogel for substitutional and regenerative surgery, obtained from hydrolysate of embryonic or postnatal collagen-containing tissues of animal origin, excluding human, which consists of two constituents: hard - microparticles from linked hydrolysate and liquid - from initial hysrolysate, taken in specified ratio, with particle size not exceeding 100 mcm. Method of obtaining injection hydrogel includes crush of initial raw material, freezing obtained mass under definite conditions, following defrosting, processing with solution of icy acetic acid, separation of supernatant liquid, washing with water, processing with sodium hydroxide solution, centrifuging obtained hydrolysate of animal tissues in form of hydrogel mass with its further filtration, part of obtained hydrolysate is processed by γ-irradiartion in dose 1.0 kGy in gaseous medium and homogenised until particles with size not larger than 100 mcm are obtained, washed with phosphate buffer solution and mixed with remaining volume of initial hydrolysate of animal tissues, obtaining injection heterogeneous elastically-resilient biodegradable biopolymer hydrogel.

EFFECT: hydrogel possesses immunogenicity, prolonged effect of biostimulating properties.

5 cl, 4 dwg, 3 tbl, 6 ex