CATIONIC LIPID Russian patent published in 2021 - IPC C07D211/36 C07D209/52 C07D211/62 C07D241/04 A61K31/7105 A61K47/22 A61K47/44 A61P43/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a cationic lipid which can be used to deliver nucleic acid into the cytoplasm. According to the present invention, the cationic lipid is a compound of formula (1a), or a pharmaceutically acceptable salt thereof, where in formula (1a) L₁ and L₂ independently represent alkylene group containing from 3 to 10 carbon atoms; R₁ and R₂ independently represent an alkyl group containing from 4 to 22 carbon atoms, or an alkenyl group having from 4 to 22 carbon atoms; X₁ is a single bond or -CO-O-; and ring P is represented by any of formulas (P-1), (P-2), (P-4) and (P-5), where R₃ is an alkyl group containing 1 to 3 carbon atoms.

EFFECT: cationic lipid is proposed.

15 cl, 20 tbl, 64 ex, 2 dwg