COMPOUNDS AND COMPOSITIONS FOR SUPPRESSING SHP2 ACTIVITY Russian patent published in 2021 - IPC C07D471/04 C07D401/14 C07D403/14 C07D487/04 C07D495/04 C07D513/04 A61K31/4545 A61K31/497 A61K31/519 A61P35/00 

FIELD: organic chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, namely, the heterocyclic compound of formulas I and II. R1 is selected from

. R2 and R3, together with the nitrogen atom to which both R2 and R3 are attached, form a ring selected from piperidinyl, piperazinyl, 2-oxo-8-azaspiro[4.5]decan-8-yl, 8-azaspiro[4.5]decan-8-yl and pyrrolidinyl. The specified pyrrolidinyl, piperazinyl, 2-oxa-8-azaspiro[4.5]decan-8-yl, 8-azaspiro[4.5]decane-8-yl or piperidinyl are not substituted or are substituted by 1-3 groups independently selected from the amino group, methyl, ethyl, amino-methyl, methyl-amino group, hydroxyl, cyano group, fluor-methyl, fluoride and ((((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)amino) methyl. R4 is a hydroxyl. R5 is selected from H and methyl. R6 is selected from hydrogen, methyl, and phenyl. R7 is selected from hydrogen, methyl, ethyl, phenyl, and benzyl. R8 is selected from hydrogen and methyl. Y1 is selected from N and CH. Y2 is CH. Y3 is selected from NH and CH2. Y4 represents N. Y5 represents N. The invention also relates to a pharmaceutical composition based on a compound of formula I or II, a method for treating a disease or disorder mediated by SHP2 activity, based on the use of this compound, and to specific heterocyclic compounds.

EFFECT: technical result is obtaining new heterocyclic compounds capable of inhibiting SHP2.

10 cl, 7 tbl, 67 ex