CATIONIC LIPID Russian patent published in 2022 - IPC C07C229/12 C07C271/20 C12N15/11 

FIELD: biotechnology.

SUBSTANCE: invention relates to a compound represented by the formula (I) or its salt, which are capable of transferring nucleic acid to a cell with high efficiency. In the formula (I), n1 is equal to an integer from 2 to 6, n2 is equal to an integer from 0 to 2, n3 is equal to an integer from 0 to 2, L is -C(O)O- or -NHC(O)O-, Ra is a linear C_5-13 alkyl group, a linear C_13-17 alkenyl group, or a linear C₁₇ alkadienyl group, Rb is a linear C_2-9 alkyl group, Rc is a hydrogen atom or a linear C_2-9 alkyl group, Rd is a hydrogen atom or a linear C_2-9 alkyl group, Re is a linear C_2-9 alkyl group, and Rf is a linear C_2-9 alkyl group. The invention also relates to 3-((5-(dimethylamino)pentanoyl)oxy)-2,2-bis((octanoiloxy)methyl)propyl 4,5-dibutylnonanoate, 2-(((4,5-dibutylnonanoyl)oxy)methyl)-2-(((5-(dimethylamino)pentanoyl)oxy)methyl)propane-1,3-diyldidecanoate, 3-((6-(dimethylamino)hexanoyl)oxy)-2,2-bis((octanoiloxy)methyl)propyl 4,5-dibutylnonanoate, 3-((5-(dimethylamino)pentanoyl)oxy)-2,2-bis((octanoiloxy)methyl)propyl 4,5-dipentyldecanoate, 3-((5-(dimethylamino)pentanoyl)oxy)-2,2-bis((octanoiloxy)methyl)propyl 4-heptylundecanoate or their salts, a lipid particle, and a composition for transfer of nucleic acid containing the specified compounds.

EFFECT: obtainment of a cationic lipid.

10 cl, 13 tbl, 21 ex