FIELD: biotechnology.
SUBSTANCE: present invention relates to the field of biotechnology, in particular to a lipopeptide, aimed at inhibiting HIV, and can be used in medicine. Invention enables to obtain a polypeptide which is capable of effective inhibition of the stage of HIV penetration into a mammalian cell (human or primate), and a corresponding lipopeptide formed by conjugation of said polypeptide with a lipophilic compound, for example a fatty organic acid, or derivatives thereof. Due to its mechanism of action, the invention can be used both for therapy of HIV-infected patients, and as an agent for prevention of HIV infection.
EFFECT: in comparison with known analogues, the anti-HIV activity of the lipopeptide of the present invention is higher than the T-20 activity by several thousand times, and is also substantially higher than the activity of the known anti-HIV lipopeptides, such as C34-Chol, LP-19 or similar.
17 cl, 10 dwg, 10 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF INHIBITION OF RETROVIRAL INFECTION (VARIANTS), PROTEASE INHIBITOR, NUCLEIC ACID ENCODING AN INHIBITOR AND A METHOD OF RECOMBINANT SERINE PROTEASE INHIBITOR PRODUCING | 1993 |
|
RU2126266C1 |
| CONSTRUCTED HIGH-AFFINITY HUMAN T-CELL RECEPTORS | 2014 |
|
RU2729383C2 |
| ISOLATED POLYPEPTIDES BASED ON NEUTRALISING OF PROTEIN p17 OF HIV VIRUS, USED AS VACCINES, AND NEUTRALISING ANTI-p17-ANTIBODIES, SPECIFICALLY RECOGNISING SAID NEUTRALISING | 2002 |
|
RU2337922C9 |
| DERIVATIVES OF PROTEIN FUSED WITH Fc WITH HIGH DOUBLE ACTIVITY: ANTIVIRAL ACTIVITY RELATIVELY TO HIV AND IMMUNOMODULATING ACTIVITY | 2018 |
|
RU2774782C2 |
| IMMUNOGENS FOR VACCINATION AGAINST HIV | 2013 |
|
RU2721274C2 |
| METHODS FOR TREATMENT OF DANON'S DISEASE AND OTHER AUTOPHAGY DISORDERS | 2017 |
|
RU2777571C2 |
| VIRUS-LIKE PARTICLES WITH HIGH-DENSITY COATING FOR INDUCTION OF ANTIBODY EXPRESSION | 2017 |
|
RU2813282C2 |
| MUTATIONS IN OAS1 GENES | 2006 |
|
RU2465328C2 |
| ANTIMICROBIAL PEPTIDE | 2014 |
|
RU2695455C2 |
| CHIMERIC HUMAN MESOTHELIOGEN ANTIGEN RECEPTORS AND USE THEREOF | 2014 |
|
RU2714902C2 |
