OPHTHALMIC PHARMACEUTICAL COMPOSITIONS Russian patent published in 2024 - IPC A61K31/496 A61K31/53 A61P27/02 A61P27/04 

FIELD: pharmaceutical industry.

SUBSTANCE: group of inventions relates to a method of treating a human patient in need of increased production of lachrymal fluid, and a method of treating a human patient with dry eye syndrome. Method of treating a human patient in need of increased lachrymal fluid, comprises local administration to a human eye once or twice a day at least 5 micrograms of compound A, having formula

or a pharmaceutically acceptable salt thereof, wherein local administration is effective to provide a concentration of compound A of at least 500 nM in lachrymal fluid from 1 hour to 12 hours after administration. Method of treating a human patient with dry eye syndrome involves local introduction of at least 5 micrograms of compound A once or twice a day into the eye of the human patient, having the above formula, or a pharmaceutically acceptable salt thereof, wherein local administration is effective to provide a concentration of compound A of at least 500 nM in lachrymal fluid from 1 hour to 12 hours after administration.

EFFECT: use of the group of inventions enables to increase production of lachrymal fluid in a patient in need thereof, by providing a concentration of compound A of at least 500 nM in lachrymal fluid from 1 hour to 12 hours after administration.

3 cl, 7 dwg