FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention relates to a simple ether derivative of nicotinyl alcohol of formula (IA-1), or a pharmaceutically acceptable salt or stereoisomer thereof;
,
where R3 is selected from substituted C1-C8 saturated alkylamino, substituted C2-C6 unsaturated alkylamino, substituted N-containing C2-C6 heterocycle-1-yl, where each is mono- or di-substituted substitute(s), selected from hydrogen, hydroxy, C1-C5 alkyl, acetylamino, cyano, methanesulfonylamino (-NH-SO2CH3), hydroxyformyl (-COOH), C1-C8 alkoxylcarbonyl, 
; X is a chlorine atom. As well as a method for production thereof, a pharmaceutical composition and use for treating diseases associated with PD-1/PD-L1 signaling channels, such as cancer, infectious diseases and autoimmune diseases.
EFFECT: simple ethereal derivative of nicotinyl alcohol, preparation and pharmaceutical composition and applications are proposed.
10 cl, 11 tbl, 29 ex, 14 dwg
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