FIELD: biotechnology.
SUBSTANCE: invention relates to modified blood coagulation protein containing blood coagulation protein, selected from the group consisting of factor IX (fIX), factor VIII (fVIII) or of biologically active elements and derivates; and at least one water- soluble polymer which is polysialic acid (PSA), which is modified by cross-linking agent connected with said blood coagulation protein from (a) one or more oxidized carbohydrate elements, where said cross-linking agent contains 1-50 ethylene glycol units, and where said blood coagulation protein has oxime bond between specified one or more oxidized carbohydrate elements and said cross-linking agent based on water-soluble polymer.
EFFECT: improved quality of modified blood coagulation protein.
19 cl, 8 dwg, 3 tbl, 16 ex
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