COMPOSITION FOR TARGETED DELIVERY OF BIOLOGICALLY ACTIVE COMPONENT INTO LARGE INTESTINE AND ITS APPLICATION Russian patent published in 2021 - IPC A61K9/20 A61K47/38 A61K35/747 A61K35/745 A61P1/00 A23L33/135 

FIELD: pharmaceutical industry.

SUBSTANCE: group of inventions relates to a composition for targeted delivery of a biologically active component into the large intestine. Composition for targeted delivery of biologically active component into large intestine containing hydroxypropyl methyl cellulose, biologically active component and an auxiliary substance, wherein the weight percentage of hydroxypropyl methyl cellulose is 40–90 %, weight percentage of the biologically active component is 10–40 %, and the weight percentage of additive is 0–50 %; and wherein the viscosity of hydroxypropyl methyl cellulose ranges from 4,000 MPa⋅sec to 200,000 MPa⋅with; and the biologically active component is a probiotic. Composition for targeted delivery of a biologically active component into the large intestine, which contains a composition. Use of the composition for preparing the composition for targeted delivery of the biologically active component into the large intestine. Method for preparing the composition for targeted delivery of a biologically active component into the large intestine.

EFFECT: composition described above provides the improved efficacy of targeted delivery into the large intestine and high bioavailability and activity of the biologically active component in-vivo, percentage of probiotic release in large intestine is more than 45 %.

9 cl, 7 ex, 2 tbl, 2 dwg