COMPOSITIONS INCREASING THE NUMBER OF COPIES OF THE VECTOR (VCN), AND METHODS OF USING Russian patent published in 2021 - IPC C12N5/789 C12N5/10 

Abstract RU 2744603 C2

FIELD: biochemistry.

SUBSTANCE: invention relates to a method for CD34+ population transduction of hematopoietic stem cells or progenitor cells, including culturing said cells in a culture medium in the presence of a lentiviral vector, an agent which enhances the transmission of prostaglandin EP receptor signals, and a poloxamer.

EFFECT: invention allows improving transduction efficiency of haematopoietic stem cells and precursor cells.

11 cl, 27 dwg, 32 ex

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RU 2 744 603 C2

Authors

Bonner, Melissa

Negre, Olivier

Dates

2021-03-11Published

2017-02-10Filed