METHOD OF TREATMENT OF MALIGNANT BRAIN GLIOMAS Russian patent published in 2021 - IPC A61N2/00 A61N5/00 

FIELD: medicine; oncology.

SUBSTANCE: invention relates to medicine, namely to oncology, it can be used for the treatment of malignant brain gliomas. Cytoreductive removal of the tumor and radiation therapy are performed. In addition, starting from 2 days after the operation and then daily for 10 days, a course of transcranial activation magnetic therapy is performed in a programmed double-exposure mode. The first impact is carried out on the hypothalamus area by an ultra-low-frequency magnetic field in the frequency algorithm of 0.3 Hz 5 min - 3.0 Hz 1 min - 9.0 Hz 1 min with an exponential intensity mode from 3 to 1 MT in the period from 8-9 am. After 2.5-3 hours, a second impact on the tumor bed is performed with a pulsed magnetic field in the same frequency sequence and a total exposure of 7 minutes with an induction of 15 MT. The next course of transcranial magnetic therapy begins simultaneously with radiation therapy and continues in binary mode throughout its duration. The effect of an ultra-low-frequency magnetic field on the hypothalamus area is carried out 1-1.5 hours before the session of conformal radiation therapy. After ionizing radiation with a percentage depth dose (PDD) of 2Gy, after 1-1.5 hours, a second impact with a pulsed magnetic field is performed on the tumor bed and the zone of perifocal edema.

EFFECT: method provides a reduction in the volume of the brain tumor remaining after cytoreductive surgery, and a significant reduction in the volume of perifocal edema of healthy glial tissue after the end of radiation therapy due to a combination of exposure of ultra-low-frequency and pulsed magnetic fields and radiation therapy.

1 cl, 2 tbl, 2 ex, 7 dwg