METHOD FOR ASSESSING CLINICALLY SIGNIFICANT CHRONIC KIDNEY DISEASE Russian patent published in 2021 - IPC A61B8/06 

FIELD: medicine.

SUBSTANCE: invention relates to nephrology, functional diagnostics, and can be used to assess chronic kidney disease stage 3-5. For this, an ultrasound examination of the skin with a high-frequency sensor is carried out on the palmar surface of the distal phalanx of the middle finger of the left hand. An ultrasound image of a skin area with visualization of the dermis and subcutaneous fat is displayed on the monitor screen of an ultrasound apparatus, followed by an assessment of the percentage of the number of echo-positive and echo-negative pixels in the ultrasound image area - indicator P1. Then, at the beginning of the venous phase of the contrast-enhanced ultrasound examination of the kidneys, timing is started, 15 seconds are counted, and a high-frequency ultrasound examination of the skin is performed 7 times every 30 seconds with an assessment of the percentage ratio of the number of echo-positive and echo-negative pixels in the ultrasound image of the skin area - the group of indicators P2-P8. After that, the difference between the arithmetic mean of P2-P8 and P1 is calculated. If this difference is less than or equal to 12%, a conclusion is made about the presence of chronic kidney disease of 3-5 stages. If this difference is more than 12%, but less than 19%, they conclude that the patient does not have chronic kidney disease of 3-5 stages.

EFFECT: method provides for the determination of chronic kidney disease stage 3-5 by assessing the presence and severity of peripheral microcirculation disorders against the background of chronic kidney disease with the simultaneous use of contrast-enhanced ultrasound of the kidneys and high-frequency ultrasound of the skin, which also makes it possible to reduce the level of invasiveness, reduce the time for assessing the state of the peripheral microcirculation and to be able to conduct a semi-quantitative assessment of pathological changes at the screening stage.

1 cl, 1 dwg, 3 ex