FIELD: immunology.
SUBSTANCE: disclosed are CLL-1-binding domains and chimeric antigen receptor (CAR) polypeptide-containing polypeptides thereof, as well as nucleic acid coding molecules, vectors, a cytotoxic cell and a killer cell, containing a population of immune effector cells. In addition, methods of treating a mammal and conditioning a patient before cell transplantation are disclosed, as well as use of said inventions for preparing a medicinal agent and for treating the disease.
EFFECT: this group of inventions can be used in therapy of various CLL-1 related diseases.
57 cl, 34 dwg, 11 tbl, 7 ex
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