BORON-ORGANIC MONOETHANOLAMINE DERIVATIVES EXHIBITING ANTIMICROBIAL ACTIVITY Russian patent published in 2021 - IPC C07F5/04 A61K31/69 A61P31/04 

FIELD: chemistry.

SUBSTANCE: present invention relates to a method of synthesis of a boron-organic derivative of monoethanolamine by a reaction of monoethanolamine with boric acid at a molar ratio of 1:1 to 2 at a temperature of 80 to 110°C, wherein the monoethanolamine is heated to a temperature of 45 to 50°C prior to adding boric acid, and to a boron-organic derivative of monoethanolamine exhibiting antimicrobial and antifungal activity produced by the proposed method in the case when the reaction is carried out at a molar ratio of monoethanolamine and boric acid from 1:2 to less than 1:1.

EFFECT: technical result is production of an antimicrobial and antifungal agent exhibiting low toxicity with complete monoethanolamine conversion and a high yield of the target product without the need for extraction and purification thereof.

4 cl, 2 tbl, 9 ex