PROSTATIC SPECIFIC MEMBRANE ANTIGEN-TARGETED HIGH-AFFINITY AGENTS FOR PROSTATE CANCER ENDORADIOTHERAPY Russian patent published in 2021 - IPC C07D257/02 C07D401/12 A61K51/04 A61P35/00 C07B59/00

Abstract RU 2749399 C2

FIELD: biochemistry.

SUBSTANCE: invention relates to the compound of Formula (I), in which Z is CO₂Q, Q is H, m is equal to an integer, selected from a group consisting of 1, 2, 3, 4 и 5, R is -CH₂-R¹, R¹ is , wherein X is Br or I, L is C₁-C₆аalkylene, W is -(C=O)-NR²- or -(C=S)-NR²-, R²is H, n is equal to an integer, selected from a group consisting of 1, 2 и 3, Ch is a chelating agent that may contain a radioactive metal, wherein the chelating agent is or and wherein the radioactive metal is ¹⁷⁷Lu, and its pharmacologically acceptable salts. The invention also relates to a method for treating a prostate tumor.

EFFECT: new compounds have been obtained that can be used in the treatment of prostate tumors.

8 cl, 7 dwg, 4 tbl, 3 ex

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RU 2 749 399 C2

Authors

Ray, Sangeeta

Pomper, Martin G.

Dates

2021-06-09—Published

2017-03-22—Filed